克罗米酚对男性低促性腺素性功能减退症合理

纽约（路透社健康特别版）1月四日华盛顿邮报：据发表在12月出特别版的《生育与后生》杂志的一项报告援引克罗米胺对部分偏高促性腺素性功能减退的年长者病患者稳定。来自伯明翰肯塔基大学的该报告的第一作者Scott J. WhittenDr在给予路透通讯社报导谈及：“病变或获得性HH病患者在给予不作为性更大和更为偏高廉的疗程（例如注射促性腺激素类）年前来进行4个月的克罗米胺试验性疗程是稳定的。”WhittenDr和同事深入研究了克罗米胺对10名HH年长者病患者（HH是导致年长者后生的普遍因素）是否有效性。报告称克罗米胺疗程1年后，4名卡尔曼(氏)综合征病患者中只有一名病患者的受精卵浓度增加而全脑垂体功能减退症病患者的受精卵缺少患者均从未得到加强。相反，该报告援引3名成年发病的病变HH年长者病患者经过3个月克罗米胺的疗程受精卵浓度有了明显增加。目年前为止该组病患者已有两名恢复了生育能力。WhittenDr说：“除非对克罗米胺疗程从未反应，我们不会因为副作用终止对病患者使用该药物。”再一作者归纳说：“因为状况有限，对HH病患者促性腺激素药物和克罗米胺的随机深入研究难以来进行，然而利用多系列的严格选择规格对病患者来进行分级似乎帮助有利于验证克罗米胺恢复年长者偏高生育能力的有效性性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰稿人：蓝色幻想

撰稿人： 张靖